![]() These results are broadly applicable to H-NOX-mediated NO signaling in bacteria. Cellular adhesion may provide a protection mechanism for bacteria against reactive and damaging NO. Phenotypic characterization established a link between NO signaling and biofilm formation. A feed-forward loop between response regulators with phosphodiesterase domains and phosphorylation-mediated activation intricately regulated c-di-GMP levels. Phosphotransfer profiling was used to map the connectivity of a multicomponent signaling network that involves integration from two histidine kinases and branching to three response regulators. ![]() NO stimulates biofilm formation by controlling the levels of the bacterial secondary messenger cyclic diguanosine monophosphate (c-di-GMP). Here, we describe a molecular pathway for H-NOX signaling in Shewanella oneidensis. In contrast, little is known about the biological role or signaling output of bacterial H-NOX proteins. Nitric oxide (NO) signaling in vertebrates is well characterized and involves the heme-nitric oxide/oxygen-binding (H-NOX) domain of soluble guanylate cyclase as a selective NO sensor. ![]()
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